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5-HTP

The brain needs L-tryptophan and 5-hydroxytryptophan (5-HTP) to manufacture serotonin

L-tryptophan and 5-HTP are widely used alternative treatments of generalized anxiety. Both amino acids are essential for the manufacturing of serotonin in the brain. Serotonin is a neurotransmitter that plays a central role in the regulation of mood and anxiety. Greater research evidence supporting the use of 5-HTP for anxiety, together with smaller effective doses and increased CNS availability, generally make 5-HTP the preferred choice over L-tryptophan.

5-HTP reduces the severity of generalized anxiety

More research has been done on 5-HTP than l-tryptophan. In a double-blind study, 58 percent of generally anxious patients (79 total subjects) randomized to L-tryptophan 3 grams per day reported significantly greater reduction in baseline anxiety compared to individuals who received a placebo. Both animal studies and human clinical trials show that 5-HTP has anti-anxiety effects. There is some evidence that 5-HTP may inhibit panic attacks induced by carbon dioxide.

Uses of 5-HTP in integrative psychiatry

In the rapidly growing field of integrative psychiatry, prescription medications and natural supplements are often used in combination to improve treatment response and reduce side effects when medications are taken alone. 5-HTP is an example of a natural supplement that may be safely combined with a prescription anti-anxiety medication with little risk of adverse effects.

5-HTP is sold for research purposes only and is not be utilized for any other purposes.

5-MEO-DALT

N,N-Diallyl-5-methoxytryptamine (also known as 5-MeO-DALT or colloquially as Foxtrot) is a lesser-known psychedelic substance of the tryptamine class that produces short-lived psychedelic effects when administered.It is structurally related to tryptamines like 5-MeO-DiPT and DALT, although it is reported to produce distinct effects.

The effects of this substance as being primarily physical in nature, lacking the characteristic visual distortions or perceptual depth of most psychedelics. Its headspace has been described as “shallow,” albeit suited for sexual contexts due to its potent stimulating and libidinous effects. It is also reported to produce more uncomfortable cardiovascular effects such as increased blood pressure and heart rate relative to other psychedelics. This has raised questions about possible toxicity associated with long-term or heavy uses.

Physical effects:
Stimulation
Spontaneous physical sensations – The “body high” of 5-MeO-DALT can be described as a motionless, constant, sharp and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the come up and hits its limit once the peak has been reached.
Tactile enhancement
Increased heart rate[citation needed]
Increased blood pressure[citation needed]
Temperature regulation suppression
Pupil dilation

5-MeO-DALT is sold for research purposes only and is not be utilized for any other purposes

5-MEO-DIBF

5-Methoxy-N,N-diisopropylbenzofuranethylamine (also known as 5-MeO-DiBF) is a novel psychedelic substance of the benzofuran class that produces psychedelic and stimulating effects when administered. It is related in structure to 5-MeO-DiPT.

5-MeO-DiBF, or 5-methoxy-N,N-diisopropylbenzofuranethylamine, is a synthetic heterocyclic alkaloid molecule of the benzofuran class. Benzofuran is a bicyclic structure formed by the fusion of a benzene ring and a furan ring, a five member aromatic ring containing an oxygen substituent.

5-MeO-DiBF is composed of a benzofuran group attached at R3 to an amino group via an ethyl side chain. It is substituted at R5 of the benzofuran heterocycle with a methoxy (MeO) functional group CH3O−; it also contains two isopropyl chains bound to the terminal amine RN of its tryptamine backbone (DiBF).

5-MeO-DiBF likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from its efficacy at the 5-HT1A and 5-HT2 family of serotonin receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Physical effects
Stimulation
Spontaneous physical sensations
Perception of bodily lightness
Pupil dilation
Tactile enhancement
Temperature regulation suppression

5-MeO-DiBF is sold for research purposes only and is not be utilized for any other purposes.

6-APDB

6-APDB (also known as 6-(2-aminopropyl)-2,3-dihydrobenzofuran or 4-Desoxy-MDA) is a stimulant and entactogenic research chemical of the phenethylamine and benzofuran classes. It is a closely related synthetic analogue of MDA and 6-APB and broadly shares the characteristics of serotonin-selective triple monoamine releasers and reuptake inhibitors associated with other entactogenic or empathogenic compounds.

Because 6-APDB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity as a substitute or replacement for serotonergic entactogens like MDMA or MDA.

6-APDB acts as a releasing agent and triple reuptake inhibitor of the monoamine neurotransmitters known as serotonin,dopamine and noradrenaline which are the global neurotransmitters that modulate the brain’s ability to feel pleasure, motivation, reward, planning, attention and focus.

Physical effects
Spontaneous physical sensations – The “body high” of 6-APDB can be described as a moderate to extreme euphoric tingling sensation that radiates throughout the entire body.
Stimulation and Sedation – In terms of its effects on the user’s physical energy levels, 6-APDB is commonly considered to have the paradoxical ability to both be stimulating as well as sedating and relaxing. Overall, it is thought to be far less energetic than MDMA or MDA.
Vibrating vision
Dehydration
Difficulty urinating
Appetite suppression
Bodily control enhancement
Increased blood pressure
Increased bodily temperature

Increased heart rate
Increased perspiration
Perception of bodily lightness
Physical euphoria
Pupil dilation
Stamina enhancement
Tactile enhancement
Teeth grinding – This is usually only present at moderate to higher doses and is similar to what one might experience from MDMA or MDA.
Temporary erectile dysfunction

6-APDB is sold for research purposes only and is not be utilized for any other purposes.

AB-CHMINACA

AB-CHMINACA (N-[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)indazole-3-carboxamide) is a drug that acts as a potent agonist for the cannabinoid receptors which produces subjective effects somewhat similar to that of cannabis.

Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. Like other cannabinoids, AB-CHMINACA is insoluble in water but dissolves in ethanol and lipids.

Unlike cannabis,the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

Physical effects
Spontaneous physical sensations – The “body high” of AB-CHMINACA may be described as a warm, soft, pleasurable, all-encompassing tingling sensation that spreads over the body after initial ingestion.
Sedation
Motor control loss
Appetite enhancement
Changes in gravity
Perception of bodily heaviness or Perception of bodily lightness
Dehydration
Nausea

Visual effects
Recursion
Visual haze
Geometry

Cognitive effects
Emotion enhancement
Anxiety
Paranoia – All cannabinoids are capable of inducing paranoia at high doses or with chronic administration.
Thought connectivity
Thought deceleration
Conceptual thinking
analysis suppression
Dream suppression
Immersion enhancement
Psychosis

AB-CHMINACA is sold for research purposes only and is not be utilized for any other purposes.

AM-1220

AM-1220 is a drug that acts as a potent and moderately selective agonist for the cannabinoid receptor CB1, with around 19x selectivity for CB1 over the related CB2 receptor.

The (piperidin-2-yl)methyl side chain of AM-1220 contains a stereocenter, so there are two enantiomers with quite different potency, the (R) enantiomer having a Ki of 0.27nM at CB1 while the (S) enantiomer has a much weaker Ki of 217nM.

A number of related compounds are known with similar potent cannabinoid activity, with modifications such as substitution of the indole ring at the 2- or 6- positions, the naphthoyl ring substituted at the 4- position or replaced by substituted benzoyl rings or other groups, or the 1-(N-methylpiperidin-2-ylmethyl) group replaced by similar heterocyclic groups such as N-methylpyrrolidin-2-ylmethyl or N-methylmorpholin-3-ylmethyl.AM-1220 was first detected as an ingredient of synthetic cannabis smoking blends in 2010

AM-1220 is sold for research purposes only and is not be utilized for any other purposes.

AMT

Similar to the hallucinogenic DMT, AMT (a-Methyltryptamine) is a psychedelic stimulant that acts upon the serotonin receptor.

AMT is available in both powder and pellet form, and was developed in the 1960s as an anti-depressant. Effects include euphoria, heightened empathy towards others, and psychedelic awareness.

Buyrcbathsalts.com provides AMT for the purposes of in vitro comparable research only. It is not available for human consumption.

BK-2C-B

βk-2C-B (also known as Bk-2C-B, or beta-keto 2C-B) is a novel synthetic psychedelic substance of the phenethylamine chemical class that produces psychedelic effects comparable to members of the 2C-x family when administered.

Compared to its structural analog 2C-B, its effects are often described as being considerably more stimulating and less psychedelic with a significantly longer duration.

Physical effects
Spontaneous tactile sensations
Increased heart rate
Nausea
Pupil dilation
Visual effects
Enhancements
Colour enhancement
Pattern recognition enhancement
Visual acuity enhancement
Distortions
Drifting (melting, breathing, morphing and flowing)
Colour shifting
Depth perception distortions
Perspective distortions
Symmetrical texture repetition
Tracers
After images
Brightness alteration
Diffraction
Geometry
Hallucinatory states
Transformations
Internal hallucination

BK-2C-B is sold for research purposes only and is not be utilized for any other purposes.

Ephenidine

Ephenidine (also known as NEDPA and EPE) is a lesser-known dissociative substance of the diarylethylamine class. Ephenidine is an NMDA receptor antagonist that is structurally related to diarylethylamines like diphenidine and methoxphenidine. Notable effects include sedation, hallucinations, anesthesia, and out-of-body states, referred to as “dissociative anesthesia”.

Ephenidine and related diarylethylamines have been studied in humans as treatments for neurotoxic injuries.

Ephenidine is a molecule of the diarylethylamine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to Rα. An ethyl chain is bound to the terminal amine RN of the phenethylamine. Ephenidine is structurally analogous to diphenidine and MXP, but is not a piperidine dissociative. Ephenidine shares a diphenylethylamine skeleton with diphenidine and MXP, but lacks a piperidine substitution.

Ephenidine acts as an antagonist of the NMDA receptor (Ki = 66.4 nM).
The NMDA (N-methyl-D-aspartate) receptor is one of the major receptor subtypes for glutamate, the major excitatory neurotransmitter in the central nervous system (CNS). When NMDA channels are blocked,a loss of feeling (anesthesia), difficulty moving (immobilization), and at higher doses, the compound’s equivalent of the “K-hole” results.

Physical effects
Stimulation – This compound produces stimulating effects at lower doses which are less intense than that of diphenidine or methoxphenidine.
Tactile disconnection
Spatial disorientation
Pain relief
Cough suppression
Appetite suppression
Nausea

Ephenidine is sold for research purposes only and is not be utilized for any other purposes.

MDAI

5,6-Methylenedioxy-2-aminoindane (commonly known as MDAI) is an entactogen substance of the aminoindane chemical class that produces entactogenic effects when administered. Notably, this compound primarily produces the non-stimulating effects of prototypical entactogens like MDMA such as sedation, muscle relaxation, and tactile enhancement.

It acts as a putatively non-neurotoxic and highly selective serotonin releasing agent (SSRA) with neglible effects on dopamine and norepinephrine. This reportedly limits its potential at producing overtly invigorating, prosocial or euphoric effects.

MDAI has been marketed alongside research chemical entactogens like 5-MAPB, 5-APB, and 6-APB as a legal, grey-market alternative to MDMA.
MDAI, or 5,6-methylenedioxy-2-aminoindane, is a synthetic molecule of the aminoindane class with structural similarity to amphetamines.

Physical effects
Sedation – The biggest difference between MDAI and MDMA is that due to a comparative lack of dopamine reuptake inhibition.
Spontaneous physical sensations
Physical euphoria
Tactile enhancement
Vibrating vision
Increased perspiration
Temperature regulation suppression
Dehydration
Difficulty urinating
Temporary erectile dysfunction

Visual effects
The visual effects of MDAI only occur at higher doses and are reported to be only subtly psychedelic in nature. These generally include:
Visual acuity enhancement
Colour enhancement
Tracers

MDAI is sold for research purposes only and is not be utilized for any other purposes.

NM-2AI

NM-2-AI (N-methyl-2-aminoindane) is a psychoactive drug and research chemical with stimulant properties of the aminoindane chemical class.

In comparison to the more prevalent close chemical relative known as 2-AI, this compound has a lower potency, a longer duration and very similar effects. Besides this, very little is known about this substance.

NM-2-AI, or N-methyl-2-AI, is the N-methylated derivative of 2-Aminoindane and is analogous to amphetamine. It features the R3 terminal carbon of the propane chain of amphetamine bound to the benzene ring.

Physical effects
Stimulation – In terms of its effects on the physical energy levels of the user, NM-2-AI is usually considered to be energetic and stimulating in a fashion that is similar to that of amphetamine but stronger than that of modafinil or caffeine.
Increased heart rate
Dehydration
Appetite suppression
Nausea
Temporary erectile dysfunction
Increased perspiration
Increased blood pressure
Teeth grinding

After effects
Anxiety
Cognitive fatigue
Depression
Irritability
Motivation suppression
Thought deceleration
Wakefulness

NM-2-AI is sold for research purposes only and is not be utilized for any other purposes.