AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. It is part of the AM series of cannabinoids.
AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2.The 4-methyl functional analog MAM-2201 probably has similar affinities.AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity
AM-2201 metabolism differs only slightly from that of JWH-018. AM-2201 N-dealkylation produces fluoropentane instead of pentane (or plain alkanes in general).
AM-2201 has a reputation in research circles as being the most potent chemical in the cannabinoid class. A full agonist for the associated receptors, it is active in doses as small as 500 micrograms, and therefore should be handled with extreme caution to avoid involuntary inhalation.
AM-2201 is sold for research purposes only and is not be utilized for any other purposes.