Diphenidine is a lesser-known dissociative substance of the diarylethylamine class that produces dissociative and hallucinogenic effects when administered. It is structurally related to methoxphenidine and ephenidine.
Diphenidine is classified as an NMDA receptor antagonist. Members of this class induce a state known as “dissociative anesthesia” and are used in both medical and recreational contexts. These include arylcyclohexylamines like ketamine and phencyclidine (PCP), as well as dextromethorphan (DXM).
Anecdotal reports describe high doses of diphenidine producing “bizarre somatosensory phenomena and transient anterograde amnesia.
Diphenidine is a molecule of the diarylethylamine class. It contains a substituted phenethylamine skeleton with an additional phenyl ring bound to Rα. The terminal amino group of the phenethylamine chain is incorporated into a piperidine ring. Hence, diphenidine belongs to the piperidine dissociative class of compounds. Diphenidine is structurally analogous to MXP, lacking a 2-methoxy substitution on one of its phenyl rings.
Diphenidine acts as an NMDA receptor antagonist.NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the famous “hole”.
The general head space of diphenidine is often described as euphoric and clear-headed in comparison to that of ketamine and reminiscent of ephenidine at lower dosages. Moderate or higher dosages can sometimes unwillingly turn very confusing and dysphoric without any apparent cause.
Diphenidine is sold for research purposes only and is not be utilized for any other purposes.