3-MeO-2′-Oxo-PCE (commonly known as Methoxetamine, MXE, Mexxy, among others) is a dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered. It is structurally related to ketamine, PCE, and 3-MeO-PCP.
Methoxetamine, or (RS)2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone, is classed as an arylcyclohexylamine. Arylcyclohexylamines are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group.
MXE acts as a non-competitive NMDA receptor antagonist and serotonin-reuptake inhibitor.NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open.Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.” MXE was reported to be similar to ketamine, despite being stronger and having a longer duration.
Because of its structural similarity to 3-HO-PCP, it was falsely believed to carry opioid properties.
Spontaneous bodily sensations
Perception of bodily lightness
Motor control loss
Methoxetamine is sold for research purposes only and is not be utilized for any other purposes.