Metizolam (also known as Desmethyletizolam) is a synthetic depressant of the thienodiazepine chemical class that reportedly produces etizolam-like effects such as anxiety suppression, disinhibition, sedation, muscle relaxation and memory suppression when administered. It is half as potent and has a 60% longer half-life than etizolam.
Metizolam, or desmethyletizolam, is a structural relative of benzodiazepines whereby the benzene ring has been replaced by a thiophene ring, classifying it as a thienodiazepine. It differs structurally from its parent compound etizolam through the removal of the methyl group on the triazole ring.
Metizolam contains a thiophene ring fused to a diazepine ring, which is a seven member ring with the two nitrogen constituents located at R1 and R4. Thiophene is a five member aromatic ring with one sulfur atom. This forms the thienodiazepine core of metizolam. An ethyl chain is bound to this bicyclic structure at R7.
Thienzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of metizolam on the nervous system.
Motor control loss
Metizolam is sold for research purposes only and is not be utilized for any other purposes.