THJ-018 (1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone) is a synthetic cannabinoid and analog of JWH-018. It has been marketed by many research chemical vendors as a legal alternative to the popular JWH-018.Its appearance is a brown, sticky and chunky powder. It smells very similarly to naphthalene. Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-018 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.
THJ-018,or 1-naphthalenyl(1-pentyl-1H-indazol-3-yl)-methanone, is a synthetic cannabinoid containing a substituted indazole structure. THJ-018 is substituted at R1 with a pentyl chain.Additionally, the indazole core is substituted at R3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings.
THJ-018 has a similar binding profile to that of JWH-018 and matches many of the in vivo properties of Δ9-THC. As with JWH-018, THJ-018 exhibits its range of effects via full agonism of both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. THJ-018 is around 5x the potency of Δ9-THC.
Spontaneous physical sensations
Motor control loss
Pain relief – Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB1 and CB2, which extends to synthetic cannabinoid receptor agonists.
Perception of bodily lightness
Changes in gravity
THJ-018 is sold for research purposes only and is not be utilized for any other purposes.